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What is Endometriosis

Endometriosis is a disorder of the female reproductive system. In endometriosis, the endometrium, which normally lines your uterus, grows in other places as well. Most often, this growth is on your fallopian tubes, ovaries or the tissue lining your pelvis.

When endometrial tissue is located elsewhere in your body, it continues to act as it normally would during a menstrual cycle: It thickens, breaks down and bleeds each month. Because there's nowhere for the blood from this displaced tissue to exit your body, it becomes trapped, and surrounding tissue can become irritated.

Trapped blood may lead to cysts, scar tissue and adhesions — abnormal tissue that binds organs together. This process can cause pelvic pain, especially during your period. Endometriosis also can cause fertility problems.

Causes

Endometriosis is believed to be a condition caused by excess estrogen created each month in the female body, and is seen primarily during the reproductive years. In experimental models, excess estrogen is necessary to induce or maintain endometriosis. Medical therapy is often aimed at lowering estrogen levels to control the disease. It is hypothesized that excess estrogen levels may be measured by a female taking her morning temperature (with a thermometer showing a tenth decimal) at the same time each day for a month or two.

A normal woman's body temperature varies from 97.5 to 98.5 degrees Fahrenheit (36.3 to 36.9 degrees Celsius), however it is hypothesized that someone with endometriosis may see temperatures of 97.0 to 98.5 °F (36.1 to 36.9°C). The lower temperatures signify the estrogen phase of a normal female's cycle, therefore it is logical that women with excessively lower body temperatures, may have an excess of estrogen, thus endometriosis. Research is needed to determine the reliability of using waking temperatures to diagnose endometriosis and its severity. Additionally, the current research into Aromatase, an estrogen-synthesizing enzyme produced by the implants themselves, has provided evidence as to why and how the disease persists after menopause and hysterectomy.

One theory holds that menstrual blood containing endometrial cells flows back through the fallopian tubes, takes root and grows. Another hypothesis proposes that the bloodstream carries endometrial cells to other sites in the body. Still another theory speculates that a predisposition toward endometriosis may be carried in the genes of certain families. A faulty immune response also may contribute to the development of endometriosis.

Other researchers believe that certain cells present within the abdomen in some women retain their ability to become endometrial cells. These same cells were responsible for the growth of the women's reproductive organs at the embryo stage. It's believed that genetic or environmental influences in later life allow these cells to give rise to endometrial tissue outside the uterus.

Treatments and drugs

Before opting for surgery, doctors recommend trying conservative treatment approaches first.

Pain medications. Your doctor may recommend that you take an over-the-counter pain reliever, such as ibuprofen (Advil, Motrin IB, others), to help ease painful menstrual cramps. However, if you find that taking the maximum dose doesn't provide full relief, you may need to try another treatment to manage your signs and symptoms.

Complementary or Alternative medicine are used by many women to get relief from the pain and discomforts from a variety of available treatments.

Hormone therapy. Supplemental hormones are effective in reducing or eliminating the pain of endometriosis. That's because the rise and fall of hormones during a woman's menstrual cycle causes endometrial implants to thicken, break down and bleed. In fact, if hormonal therapy has little to no effect on your symptoms, consider questioning the diagnosis of endometriosis or its relationship to your symptoms.

Many women are using Natural Progesterone Cream to help treat Endometriosis. This treatment regime is also gaining popularity among the medical profession to help reduce symptoms and aid treatment of Endometriosis.

Progesterone or Progestins, counteracts estrogen and inhibits the growth of the endometrium. Such therapy can reduce or eliminate menstruation in a controlled and reversible fashion. Progestins are chemical variants of natural progesterone. Avoiding products with xenoestrogens, which have a similar effect to naturally produced estrogen and can increase growth of the endometrium.

Natural Progesterone cream is not the same as progestin in prescription birth control pills, or the progestin used in the treatment of Endometriosis. These prescription hormones are chemically modified from the natural hormones to be different in order to be patented. This then allows pharmaceutical companies to manufacture these chemically based hormones for profit.

Since these chemically modified hormones are not naturally found in nature or in the body, they have many potentially dangerous side effects. In contrast, natural progesterone is bio-identical to the hormone in your body, and is compatible with the human body with a minimal amount of side effects.

Do Not Use Progestins With Progesterone

Synthetic Progestins such as Megestrol and Provera compete with the receptor/binding sites normally reserved for Progesterone. Progesterone taken together with these synthetic hormones will not work. You are advised to withdraw from using synthetic Progestins gradually before starting to use Natural Progesterone for treatment of Endometriosis.

Finding The Right Progesterone Cream

Many women have thought Wild Yam extract cream and progesterone cream are the same thing. The fact is they are not. Many companies are marketing a cream made from wild yam extract and telling customers that their body is going to convert wild yam extract into progesterone. This is not true. Many (bioidentical) progesterone creams do not contain the amount of progesterone as advertised and are not willing or able to provide laboratory test results to back up their claims.

There are Progesterone creams on the market, which are being used successfully by women with Endometriosis, to help them deal with the disease, and to help with estrogen dominance. The only successful results however, are from those creams which contain a synthetic natural progesterone. This means that the progesterone being sythesized is identical to the human hormone progesterone at a molecular level.

Natural Progesterone Cream must be free of toxic chemicals and preservatives. Free of Methyl Paraben, Propyl Paraben, Butyl Paraben or any of the related Parabens or estrogenic herbs. Free of ethoxylated wetting agents, such as PEG 8 Stearate, PEG 100 Stearate, Polyethylene Glycol, Polysorbate 60, or Polysorbate 80, which may be contaminated with 1,4-dioxane, a known carcinogen. Free of mineral oil. Mineral oil blocks the absorption of natural (bioidentical) progesterone. Free of Stearal Konium Chloride, a toxic emulsifiers.

750 mg/ounce of USP progesterone or 1500 mg/ounce of USP progesterone is suggested for severe symptoms of hormonal imbalance the treatment of endometriosis.

Oasis Serene Progesterone Cream is only Progesterone cream on the market today that meets these requirements.

It will never be completely identical as we cannot replicate nature, but it will be as close as possible. So this ‘natural progesterone’ is synthetic and is made in a laboratory.

Many (bioidentical) progesterone creams do not contain the amount of progesterone as advertised and are not willing or able to provide laboratory test results to back up their claims. This is not the case with Oasis Serene Progesterone Cream . They stand behind their natural progesterone cream!

Other Hormonal therapies used to treat endometriosis include:

Hormonal contraceptives. Birth control pills, patches and the vaginal ring help control the hormones responsible for the buildup of endometrial tissue each month. Most women have lighter and shorter menstrual flow when they're using a hormonal contraceptive. Using hormonal contraceptives — especially continuous cycle regimens — can reduce or eliminate the pain of mild to moderate endometriosis.

Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists. These drugs block the production of ovarian-stimulating hormones. This action prevents menstruation and dramatically lowers estrogen levels, causing endometrial implants to shrink. Gn-RH agonists and antagonists can force endometriosis into remission during the time of treatment and sometimes for months or years afterward. These drugs create an artificial menopause that can sometimes lead to troublesome side effects, such as hot flashes and vaginal dryness. A low dose of estrogen may be taken along with these drugs to decrease such side effects.

Danazol. Another drug that blocks the production of ovarian-stimulating hormones, preventing menstruation and the symptoms of endometriosis, is danazol. In addition, it suppresses the growth of the endometrium. However, danazol may not be the first choice because it can cause unwanted side effects, such as acne and facial hair. Medroxyprogesterone (Depo-Provera). This injectable drug is effective in halting menstruation and the growth of endometrial implants, thereby relieving the signs and symptoms of endometriosis. Its side effects can include weight gain, decreased bone production and depressed mood.

Aromatase inhibitors. These agents, known for their effectiveness in treating breast cancer, also may be useful for endometriosis. Aromatase inhibitors work by blocking the conversion of hormones such as androstenedione and testosterone into estrogen and by blocking the production of estrogen from endometrial implants themselves. This deprives endometriosis of the estrogen it needs to grow. Early studies suggest that aromatase inhibitors are at least as good as other hormonal approaches and may be better tolerated. Hormonal therapies aren't a permanent fix for endometriosis. It's possible that you could experience a recurrence of your symptoms after stopping treatment.

Serotonin Modulation is an approach to pain management that has been advocated for women suffering from endometriosis. involves raising one's serotonin levels. Low serotonin levels reduce the pain threshold, and make people more susceptible to pain.

In Asia, especially Korea and Northern China, herbal formulas are prescribed to help the body regulate the abnormal cellular growth that causes endometriosis. Chinese Herbal Therapy for Endometriosis .

Nutrition: There has been research[citation needed] showing that prostaglandins series 1 and 3 have an anti-inflammatory effect which can help with endometriosis. Proper nutrition may also help to boost the immune system, which could be helpful if immune deficiencies contribute to endometriosis.

Coffee and alcohol should be avoided as both can increase the levels of estrone.

Some women with gluten sensitivity may be helped by avoiding wheat and wheat products.

While it can't cure endometriosis, acupuncture can be used as a palliative to treat the pain associated with menstrual cramps, back symptoms, and endometriosis adhesions.

If your pain persists or if finding a treatment that works takes some time, you can try measures at home to relieve your discomfort. Warm baths and a heating pad can help relax pelvic muscles, reducing cramping and pain.

Finding a doctor with whom you feel comfortable is crucial in managing and treating endometriosis. You may also want to get a second opinion before starting any treatment regimen to be sure you know all of your options and the possible outcomes.

References

1. Endometriosis From Wikipedia, the free encyclopedia.
2. Mayo Clinic Women's Health - Endometriosis
3. Diagnosis and Treatment of Endometriosis - Caroline Wellbery, Georgetown
    University School of Medicine
4. Aromatase Expression in Postmenopausal Endometriosis - from Seminars
    in Reproductive Medicine.
5. Endometriosis Cancer Risk - Medical News Today.
6. Endometriosis - Sanaz Memarzadeh, MD, Kenneth N. Muse, Jr., MD,
    & Michael D. Fox, MD


These statements are not intended to diagnose, treat, cure, or prevent any disease. They are for informational purposes only.

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